Journal article
Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering
RC Laker, GD Wadley, GK McConell, ME Wlodek
Journal of Developmental Origins of Health and Disease | Published : 2012
Abstract
Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering would ameliorate these deficits. Bilateral uterine vessel ligation (Restricted) or sham (Control) surgery was performed on day 18 of gestation. Males and females were investigated at day 20 of gestation (E20), 1 (PN1), 7 (PN7) and 35 (PN35) days postnatally. A separate cohort of Control and Restricted pups were cross-fostered onto a different Control or Restricted mother and exam..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank Andrew Jefferies and Kerryn Westcott for assistance with animal surgery and handling and Dr Andrew Siebel for assistance with cross-fostering and real-time PCR. This research was supported by a grant from the Diabetes Australia Research Trust and the National Health and Medical Research Council (no. 454570). RCL was supported by Sheppard M Lowe Scholarship (Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, 2007) and co-funded NHMRC/NHF Biomedical Postgraduate Scholarship (2008-2010).